Fermentable fibers, which are found in various kinds of fruits, vegetables, grains, and legumes, act in two ways to increase GLP-1 secretion
Previously, there was no agreement on what range to use, how much time should be spent in that range, and what a meaningful improvement would be
As a class, the GLP-1RAs have all been shown to have a body weight-reducing effect without clinically significant differences in body weight reduction between short-acting and long-acting GLP-1RAs
Therefore, the native peptide cannot be used therapeutically
They slow gastric emptying, increase satiety signals to the brain, and reduce the drive to overeat