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Qin L, Chong T, Rodriguez R, Pugazhenthi S (2016) Glucagon-like peptide-1-mediated modulation of inflammatory pathways in the diabetic brain: relevance to Alzheimers disease

This dual action of tirzepatide potentially offers broader benefits, particularly in weight management and glycemic control, compared to semaglutide's singular focus

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Among 12,519 patients with at least two years of follow-up after initiation, dose escalation and weight change during the first two years (pre-landmark period) were evaluated in relation to cardiovascular outcomes during the subsequent two years (post-landmark period)

As in other chronic respiratory diseases, excessive NE proteolytic activity causes tissue damage and disease progression by degrading proteins essential for maintaining alveolar structure (62), increasing apoptosis and necrosis in the lungs, and activating senescence in airway epithelial cells (63, 64)