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4 Ferroptosis in retinal cells 4.1 Regulatory mechanisms and pathological roles of ferroptosis in RPE cells Retinal pigment epithelial (RPE) cells are located between the choroid and photoreceptors, undertaking core functions such as phagocytosis of photoreceptor outer segments, transport of nutrients, and inhibition of oxidative stress

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10.1016/j.cell.2020.02.008

The reaction was carried out using 1 M SHMT1 or 4 M SHMT2 in 50 mM potassium phosphate, pH 7.5, containing 1 mM EDTA, 5 mM 2-mercaptoethanol, 0.5 mM NAD + and 8 M TMABADH, at 37 C