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However, Aja and colleagues found no evidence for this hypothesis since in this model CPT-1 should inhibit feeding by increasing cytosolic fatty-acyl CoA levels while they actually showed the initial response of mice to a CPT-1 inhibitor was an increase in appetite [75]

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LIRA a dosis de 1,8mg diarios induce mejora de la enfermedad esteatsica heptica asociada a disfuncin metablica (MASLD) con resolucin de esteatohepatitis en el 39% de los casos, mientras que la fibrosis progres en el 9% de los pacientes, frente al 36% tratados con placebo29 (fig