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In the UPS, proteins are selectively marked by ubiquitination, the covalent addition of ubiquitin (Ub) molecules to lysine residues, which signals and targets the protein for proteolytic degradation by the 26S proteasome

The CEO of Athira, formerly known as M3 Biotechnology, is Leen Kawas, once a PhD student at Washington State whose 2011 doctoral dissertation provided figures for this fraught 2011 article in JPET , which earned a correction in 2014