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Losing significant weight during pregnancy is The FDA advises that no one should take semaglutide if they are pregnant

The study endpoints looked at the percentage of body weigh change and fraction of body weight lost

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Patients with comorbidities, such as depression, anxiety, or sedentary behavior, may experience reduced efficacy.[49] Moreover, over half of the lost weight is often regained after discontinuation.[50] Common side effects include gastrointestinal (GI) symptoms such as nausea, vomiting, and diarrhea,[51] while severe outcomes like pancreatitis or thyroid cancer have not shown significant increases.[52] Notably, weight loss does not always equate to improved health