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To explore potential differences in how men and women respond to the treatment, researchers conducted a post-hoc analysis of the SURMOUNT program, which included four clinical trials

However, there was no significant change in systolic or diastolic blood pressure and heart rate 3 months after switching to semaglutide (data not shown)

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Many individuals experience transient gastrointestinal symptoms during the initial weeks of treatment or following dose escalation, with symptoms often improving as the body adapts to the medication