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Additionally, use of proton pump inhibitors (PPIs) and diuretics (or "water pills") such as furosemide and hydrochlorothiazide can lead to magnesium deficiency over time

Instead, they assign a Beyond-Use Date (BUD) based on United States Pharmacopeia (USP) guidelines and any stability data they have generated

Iron deficiency (prevalent in 15% of adults) reduces monoamine oxidase activity, leading to 5-HT degradation and increased depressive symptoms

doi: 10.1002/jcp.31483 138