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Additionally, a one-year placebo-controlled trial in adults aged 65 years and older found that daily supplementation with a multivitamin/mineral did not benefit cognitive performance on a verbal fluency test an assessment in which participants were asked to list words starting with a certain letter in a designated time period (135)

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This association remained strong even when comparing trends in peptide levels during the first year with changes in the fasting C-peptide/glucose ratio between the baseline 6 week and 24 month measurements (FDR=0.07)

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