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GLP-1 Receptor Agonists Topic Guide Curated clips, articles, and podcast episodes GLP-1 receptor agonists (GLP-1 RA) have rapidly moved from niche diabetes therapies to some of the most widely discussedand widely prescribeddrugs for metabolic health
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decreased smooth muscle cell proliferation reduces neointimal formation Anti-inflammatory signaling: Suppression of NF-kB, reduced macrophage infiltration into plaques, and decreased secretion of IL-6, TNF-alpha, and MCP-1 from monocytes and foam cells Atherogenic lipid reduction: Improvements in LDL cholesterol, VLDL, triglycerides, and chylomicron remnants beyond what weight loss alone would predict Blood pressure reduction: Through direct vasodilation and natriuresis, independent of weight change Epicardial and perivascular fat reduction: This fat depot exerts direct paracrine inflammatory effects on the vascular endothelium and myocardium
