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PAT and other trivalent antimonials dominated chemotherapy for schistosomiasis until the introduction of praziquantel in the 1980s

Physiol Rev 78 : 9691054 Patterson Jr MK (1979) Measurement of growth and viability of cells in culture

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In naturally aged mouse models (1820 months old), daily oral administration of 5-amino-1mq capsules for 12 consecutive weeks significantly reduced NNMT activity and increased NAD+ levels in various tissues (liver, kidney, adipose tissue), along with markedly elevated expression of SIRT1 and SIRT3 proteins

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