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The potential risks of taking Phentermine and Semaglutide together could be minor or adverse and vary from one patient to another : Side effects: Some commonly reported side effects of taking Phentermine and Semaglutude include headache, unpleasant taste, dry mouth, drowsiness, nausea, nervousness, fatigue, diarrhea/constipation, thirst, abdominal pain, and trouble sleeping