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Phenylalanine is an essential amino acid which inhibits the breakdown of opiate-like substances in the brain called encephalins.1 Reduced breakdown of encephalins by phenylalanine results in analgesia (pain relief).2 Isoleucine is also involved in the production of endorphins

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This is an uncomfortable reality that most GLP-1 discussions avoid

Beyond their insulinotropic effects, coordinated GLP-1R, GIPR, and GCGR signaling also influence lipid metabolism and energy expenditure by modulating hepatic lipid handling and adipose tissue function

The transformation of dietary folate into its active monoglutamate form requires the action of the enzyme GCPII, located on the intestinal brush border