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Patients showed a 21.9% reduction in fat mass after 48 weeks of therapy while increasing lean muscle mass by 4.5%

Evaluate current indications : If you already qualify for a GLP-1 agent for diabetes, obesity, or cardiovascular risk, this brain effect adds more rationale

"We emphasize that as the clinical investigator, it is your responsibility to ensure that studies are conducted in accordance with the investigational plan, both to protect the rights, safety, and welfare of subjects and to ensure the integrity of study data." FDA noted that two of the nine randomized subjects who received the investigational product were not eligible under the enrollment criteria

Nausea, constipation, and reflux are common, especially during dose escalation, and going slower or staying lower feels like the obvious fix