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B12 deficiency specifically causes fatigue, weakness, and cognitive fog that mimics the worst aspects of retatrutide tiredness

PMID: 26483209

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Protein fermentation products such as indoxyl sulfate (IS), indole-3-acetic acid (IAA), and p-cresyl sulfate (PCS) accumulate in CKD and correlate with tubular interstitial fibrosis severity by activating the aryl hydrocarbon receptor (AHR) and NF-B signaling (48)