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Most people who develop constipation notice it within the first four weeks of starting treatment or within two weeks of any dose increase

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Ravindra et al

rhamnosus JY02 increase anti-inflammatory factors, such as IL- 10, while reducing pro-inflammatory markers, such IL- 6, and IFN-

Important safety considerations include: Cardiovascular history : Patients with established cardiovascular disease require careful assessment, though recent evidence suggests GLP-1 receptor agonists may offer cardiovascular benefits Medication interactions : No clinically significant interactions are expected between GLP-1 receptor agonists and statins or other lipid-lowering medications, though delayed gastric emptying could theoretically affect absorption of oral medications Pancreatitis risk : Whilst rare, acute pancreatitis has been reported with GLP-1 receptor agonists