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Exendin-4, a GLP-1R agonist, also suppressed basal expression of several inflammatory mediators and in combination with phosphodiesterase inhibitors, decreased CXCL10 expression by IFN- (a type II-interferon) in human islets and in MIN6 cells (a mouse -cell line)
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Major functions of VIP include airway smooth muscle relaxation [112], stimulation of mucus secretion from airway glands and goblet cells [113], and vasodilation [112, 114]
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