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The Phase 2 data, while exceptional, is preliminary by regulatory standards

It also can lead to lower testosterone levels which increase an increase in aromatase leading to high estrogen levels high estrogen levels lead to fat, particularly in the belly

Moreover, over the last few years the approach to treatment of patients with a high cardiovascular risk has totally changed from treatment aimed at a specific risk factor (i.e., glucocentricity or lipo-centricity) to effective diagnostics, monitoring, and treatment of all risk factors and general cardiovascular risk as well as concomitant diseases, stressing the role of residual risk, and the intensity of the applied therapy

And the data that existed back then wasnt very convincing