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To solve the tirzepatideGIPRG s complex structure, we introduced one mutation (T345F) to stabilize complex assembly (Supplementary Fig

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2.1 Dysbiosis of intestinal flora A reduction in the abundance and diversity of specific bacterial genera in the gut microbiota, as well as alterations in microbiota-derived metabolites, has been identified as a potential key factor in the pathogenesis of IBD (28, 29)