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Regardless, patients with TDP-43 mutations have TDP-43 pathology, and the mouse model that have A315T mutation has TDP-43 accumulations mostly in the nucleus, have extensive ubiquitinated protein accumulations in the cytoplasm, and based on the antibody used, pTDP-43 are also detected in the cytoplasm 19,46

doi: Research C for DE and

Results: In vitro assays revealed that the variant demonstrated a tendency towards decreased DNA binding compared to the wild type (52% lower than wild type, n=9, p=0.86)

BMI was calculated as body weight in kilograms divided by height in meters squared (kg/m 2 )