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J Alzheimers Disease: JAD 86(1):259270

T.WarneJ

No Ipamorelin is selective for the ghrelin receptor (GHS-R1a) and does not stimulate ACTH, cortisol, or prolactin secretion the way earlier secretagogues like GHRP-6 or GHRP-2 did

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It is not entirely clear how ALLO, which is a positive allosteric modulator of GABAergic neurotransmission, acts to improve memory function in this patient population, but it has been suggested that stress-induced changes in GABA receptor expression levels are likely to play a role in the etiology of depression