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In ME/CFS ( n = 15) and FM ( n = 15) samples no significant differences between the two groups was observed although both were very different from the healthy control group (Schutzer et al., 2023)

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An overview of clinical features can be found in Supplementary Table 1

After a 2 week screening period all eligible participants were randomly assigned to treatment groups receiving either a subcutaneous injection of 2.4 mg of semaglutide, 2.4 mg of cagrilintide, a combination of cagrilintide and semaglutide, a semaglutide placebo, or a cagrilintide placebo [2]