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Most compounding pharmacies assign BUDs based on three factors: the sterility of their compounding environment, the results of any stability testing they have conducted, and the default guidelines from USP 797

If you have not had low B12 confirmed, that check with your GP comes first

Keep consecutive injections at least one inch apart from any previous site, and avoid any area that is bruised, scarred, inflamed, or still tender from a previous dose

Elderly people due to impaired intestinal absorption and children, premenopausal women, and pregnant women whose diets are low in animal foods are all at increased risk

Thats why sudden fatigue, muscle cramps, or weakness can appear during the first few weeks of B12 supplementation not because B12 isnt working, but because your potassium balance may need attention