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They also had a 59 percent lower risk of pancreatic cancer, 53 percent lower risk of liver cancer, 48 percent lower risk of ovarian cancer, 46 percent lower risk of colorectal cancer, 41 percent lower risk of multiple myeloma, 40 percent lower risk of esophageal cancer, 26 percent lower risk of endometrial cancer and 24 percent lower risk of kidney cancer

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In the sections that follow, we build on this conceptual framework to examine how major proteostasis machineries contribute to cellular and organ-level resilience and how their failure drives pathology across cardiovascular, cancer, metabolic, neurodegenerative and autoimmune disorders and highlight therapeutic strategies aimed at reinforcing proteostasis resilience