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doi: 10.1111/j.1368-5031.2006.00825.x

Glucagon-like peptide-1 (GLP-1) is an incretin hormone produced by enteroendocrine L-cells in the distal small intestine and colon in response to nutrient intake

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For those considered overweight or having obesity, losing 5% or more of initial weight is linked to lessening cardiometabolic disease risk, with reductions in blood pressure, LDL cholesterol, triglycerides, and glycemia