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Pain was measured using the Knee Injury and Osteoarthritis Outcome Score measurement scale

Weight reduction directly decreases the metabolic burden on the liver, whilst improved glycaemic control reduces lipogenesis (fat production) and enhances fatty acid oxidation

Hence, the investigated time points were in the latent phase of experimental RN, showing no evidence for OS in the latent period

The rationale is straightforward: glycine protective and supportive effects operate at consistent baseline levels, and the research supporting mTOR activation and anti-inflammatory effects shows efficacy across a range of concentrations without requiring dose escalation