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Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist

Compare systemic and localized effects in severe lesions or tendon-to-bone integration models

The approved population is not a gut-health population: In the pivotal trial the average patient had 77 cm of remaining small intestine against a normal length of roughly 6 metres, had been dependent on intravenous nutrition for a mean of 6 years , and in 44% of cases had no colon in continuity [2]

They are not interchangeable by default

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