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"Our study also underlines the current challenges with treating type 2 diabetes and obesity with these highly effective medications, as only 4 in 10 patients in our cohort had persistent medication coverage at one year," Gasoyan told Newsweek

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But fullness, appetite, and metabolic signals can still feel unpredictable

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Lipophilic drugs are often encapsulated in carriers like liposomes, nanoparticles, or emulsions to improve solubility and retention time and reduce the mucociliary clearance (Ugwoke et al., 2001)