Supplementing with B12 is common and well-supported
Indications and Usage Ozempic (semaglutide) injection 0.5 mg, 1 mg, or 2 mg and Ozempic (semaglutide) tablets 4 mg or 9 mg are indicated: as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes Ozempic injection is indicated: to reduce the risk of major adverse cardiovascular (CV) events (CV death, nonfatal myocardial infarction, or nonfatal stroke) in adults with type 2 diabetes and established CV disease to reduce the risk of sustained eGFR decline, end-stage kidney disease, and cardiovascular death in adults with type 2 diabetes and chronic kidney disease Ozempic tablets are indicated: to reduce the risk of major adverse cardiovascular (CV) events (CV death, nonfatal myocardial infarction, or nonfatal stroke) in adults with type 2 diabetes who are at high risk for these events References: Ozempic injection

In the secondary endpoint, subjects treated with tirzepatide achieved an overall mean weight loss of 26.6% after 12 weeks of intensive lifestyle intervention followed by 72 weeks of tirzepatide treatment
[DOI] [PMC free article] [PubMed] [Google Scholar] 94.stergaard S., Paulsson J.F., Kofoed J., Zosel F., Olsen J., Jeppesen C.B., Spetzler J., Ynddal L., Schleiss L.G., Christoffersen B.., et al
The affinity ratios embedded in the engineered peptides produce downstream biology that the separate components, dosed independently, do not reproduce