Expected outcomes: Possibly better preservation than AREDS2 alone, though unproven
Additionally, when succinyl-CoA is converted to succinate by succinate thiokinase, one molecule of GTP is generated, which can be readily converted to ATP by nucleoside-diphosphate kinase (NDPK)
Once reconstituted, the solution should be used promptly or aliquoted and stored at -20C to avoid repeated freeze-thaw cycles, which can degrade the compound
One such treatment that we may consider is Glutamine IV therapy
Ann Cardiol Angeiol (Paris) 55:104112 Delemasure S, Sicard P, Lauzier B, Moreau D, Vergely C, Rochette L (2007) Acute administration of Epirubicin induces myocardial depression in isolated rat heart and production of radical species evaluated by electron spin resonance spectroscopy