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Astrocyte endfeet in brain function and pathology: open questions

As with other cell types, high glucose-driven impairment in astrocytes is mediated by overproduction of reactive oxygen species and activation of nuclear factor-B and signal transducer and activator of transcription 3 inflammatory pathways

Across those trials the compound's tolerability was reported as comparable to placebo, with no statistically significant effects detected on serum IGF-1, fasting glucose, insulin, HbA1c, cortisol, or thyroid hormones at the levels studied, and no serious adverse events attributed to the compound [7]