Patients will start on a lower dose of Tirzepatide, which is gradually increased to maximize the medications effectiveness while minimizing potential side effects
Tobacco Etch Virus (TEV) Protease TEV protease is a cysteine protease from Tobacco Etch Virus that recognizes the ENLYFQS/G consensus and cleaves with high sequence specificity, enabling precise tag removal with minimal residual amino acids (often only the natural N-termial residue) [160]
[6] Factors that may prolong or worsen symptoms include: Rapid dose escalation beyond what the individual gut can tolerate High-fat, high-sugar, or heavily processed dietary intake Concurrent use of medications that can independently cause loose stools, such as metformin, magnesium-containing preparations, or orlistat a clinician should review the full medication list if diarrhoea is persistent Underlying gastrointestinal conditions such as inflammatory bowel disease or coeliac disease Real-world duration of symptoms may differ from controlled trial settings
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