glp-1 and cancer risk Emerging Evidence Positions Receptor Agonists as a Novel Strategy to Reduce CRC GLP-1 RA initiation versus metformin

Uemura K, Kuzuya A, Shimozono Y, Aoyagi N, Ando K, Shimohama S, et al

Bioinformatic studies have shown that genes associated with necroptosis are altered in the brains of PD patients compared to control subjects, suggesting an increased susceptibility to necrotic cell death in these patients (Lei et al., 2023)

Due to the interconnection of glycolysis and Oxphos, there is dynamic interchange between cytoplasmic and mitochondrial NAD + , as depletion of cytoplasmic NMNAT2 also depletes mitochondrial NAD + 77

Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression

Crefcoeur LL, Melles MC, Bruning TA, et al