Richards et al., 2014
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Even people who achieve the treatment goals with the new obesity pharmacotherapies might decide to undergo bariatric surgery to support long-term weight maintenance because either they experience weight regain on the medication or they do not have long-term access to obesity pharmacotherapy, or they prefer not to take obesity pharmacotherapy lifelong
Moreover, a significant rise in fasting levels of adiponectin by 1226% and IGF binding proteins IGFBP-1 and IGFBP-2, markers of insulin sensitivity, were reported following treatment with all doses of tirzepatide [74]
Clinical trials show average weight loss of 1022% with semaglutide and 1622% with tirzepatide over 68 weeks, outperforming phentermine's typical 510% result