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Metabolic rate typically decreases proportionally as body mass declines during GLP-1 therapy, following the same pattern as weight loss from other methods
Hence, these results indicated that VRK2 drove the ER-to-Golgi trafficking of SLC7A11 through phosphorylating Sec24C
Nevertheless, these co-agonists must be carefully monitored as a loss in GLP-1R activity could lead to excessive glucagon-mediated deleterious effects on glucose control
Data availability All data presented in the review paper is published and referenced
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