In 1 small study, women with poorer mean preconception creatinine clearance (CrCl) of 61 mL/min/1.73 m During pregnancy, serum creatinine (not eGFR) should be used, as eGFR will underestimate GFR in pregnancy (57,58)
Weeks 14 Early adjustment phase Weight loss: 26 pounds Weeks 58 More consistent progress Weight loss: 612 pounds total Patients starting structured programs including those beginning tirzepatide weight loss in Tampa often see this phase as a turning point
Schedule prompt medical evaluation (within 24-48 hours) for: Gradually worsening shortness of breath over days to weeks Dyspnea with exertion that is new or significantly worse than baseline Breathing difficulty accompanied by persistent cough or fever Leg swelling, weight gain, or orthopnea (difficulty breathing when lying flat) Respiratory symptoms associated with severe ongoing nausea, vomiting, or inability to maintain hydration Patients should not discontinue GLP-1 medications without medical guidance (except in cases of suspected severe allergic reactions), but should contact their healthcare provider promptly to discuss respiratory symptoms
Submit required medical documentation: Your provider will need to submit supporting medical documentation to demonstrate why the GLP-1 medication is necessary for your treatment
Hooda et al., 2013