[DOI] [PubMed] [Google Scholar] Hosaka T, Biggs WH, 3rd, Tieu D, Boyer AD, Varki NM, Cavenee WK, Arden KC
Effect of metformin versus metformin plus liraglutide on gonadal and metabolic profiles in overweight patients with polycystic ovary syndrome
Peptides potentially enabling successful conservative management avoiding surgical risks and recovery
On one hand, ROS-mediated damage to the cystine-glutamate antiporter SLC7A11expressed on RMECs, RPE cells, and Mller cellsimpairs cystine-cysteine biotransformation, disrupts the GSH- GPX4 antioxidant axis, and thereby triggers ferroptosis in these cell populations
Oncotarget 8(17):2806328073 Hayano M, Yang WS, Corn CK et al (2016) Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation