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Following surgery, mice were housed individually with access to standard food and water

To stop AA leaking, the animals were held upside down for two minutes

Key results at the highest dose (24 mg): 22.5% placebo-adjusted mean weight loss at 48 weeks 96% achieved at least 5% weight loss 87% achieved at least 10% weight loss 48% achieved at least 20% weight loss 26% achieved at least 30% weight loss 54% reduced BMI below the obesity threshold (30 kg/m2) versus 13% placebo No weight loss plateau at 48 weeks Discontinuation due to adverse events: 5.9% (CT-388) vs 1.3% (placebo) Preclinical Data# CT-388 improved glycemic control in mice and monkeys, reduced body weight, suppressed appetite, and improved metabolic dysfunction-associated steatohepatitis (MASH) pathology in mice

Collaborative care between primary care providers and endocrinology specialists often provides optimal management for patients with both Hashimoto's thyroiditis and metabolic conditions requiring tirzepatide therapy

At this stage, your doctor may suggest increasing the dose