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A 2025 systematic review and meta-analysis in Reviews in Endocrine and Metabolic Disorders found that tirzepatide (the active ingredient in Mounjaro and Zepbound) reduced hsCRP by approximately 33% and IL-6 by approximately 18% compared to placebo across patients with and without diabetes. A growing body of research suggests this effect occurs through direct action on the NF-B pathway, a master switch of inflammation

Focusing on foods that keep you fuller while still maintaining a healthy calorie deficit is also advised

New studies are published, refining our understanding of its pharmacokinetics, pharmacodynamics, and potential applications

Stat Med 27:57095724