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#Signals #ObesityMedicine #GLP1 #MetabolicHealth To view or add a comment, sign in REDEFINE 5: A Step Forward in Obesity Management The Phase 3a REDEFINE 5 trial demonstrated that cagrilintide + semaglutide achieved significantly greater weight loss than semaglutide alone at 68 weeks (18.4% vs 11.9%), highlighting the potential of dual amylinGLP-1 therapy as a next-generation approach to obesity treatment

The findings revealed that unlike SPLs, which contributed to an increase in the number of white adipose tissue (WAT) hypertrophy, inflammation, and liver steatosis, diets incorporating MPLs did not negatively affect adiposity or liver lipid concentrations [25]

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Phase 2 Weight Loss Trajectory (48 Weeks) The Phase 2 obesity trial published by Jastreboff et al

Gastrointestinal adverse events including nausea, vomiting, and diarrhea are common with current GLP-1 agonists, leading some patients to discontinue treatment or fail to reach maximally effective doses