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Lancet Gastroenterol Hepatol 10(1):6881

Furthermore, melatonin increases upstream precursors such as SAM and putrescine, reinforcing the biosynthetic pathway and synergistically enhancing SPMS expression 90,91

In contrast, intravenous glutathione raises serious safety concerns, including the risk of anaphylaxis and hepatotoxicity, compounded by the lack of standardized protocols and rigorous clinical studies