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Under normal physiological conditions the NO increase might be controlled by S-nitrosylation/glutathionylation of eNOS as an immediate response or by similar modification/activation of SERCA in steady-state regulation

2018 Jan;476:130-138

SAMe can also regenerate Met via methyl-thioadenosine (MTA), a byproduct of polyamines synthesis

In such circumstances, the driving force for the different cell ROS accumulating responses could be mainly contributing to the effects of MM induced by pre-LOsG treatment

Validation of high performance liquid chromatography-electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate-amodiaquine drug combination