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In summary, alterations at the glutathione activator site result in an absent geometric and electrostatic complementary 3,50 for the reducing agent, explaining the inefficient reduction of numerous glutaredoxins 12,25,26,27,28,29,48 and thioredoxins by GSH

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The Rybelsus Summary of Product Characteristics notes that it can increase levothyroxine exposure

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J Anal Toxicol 1999, 23 (2) : 134136