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Am J Physiol Endocrinol Metab (2020) 318(2):E23748
MASLD also raises your risk of an earlier death
Metformin has separately shown wound healing benefits: a 2021 randomized trial (N=108) of topical metformin on diabetic foot ulcers found a 52% complete healing rate at 12 weeks versus 31% with standard care alone (P=0.02) [11]
This activation leads to neuroprotection and the promotion of neuronal progenitor proliferation [59]
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Building upon the foundation of MetS, in 2023, the American Heart Association (AHA) introduced the cardiovascular-kidney-metabolic (CKM) Syndrome, which was defined as: A systemic disorder characterized by pathophysiological interactions among metabolic risk factors, CKD, and the cardiovascular system, leading to multiorgan dysfunction and high rates of adverse cardiovascular outcomes
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