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GLP-1 agonists are a group of medications that help to manage blood sugar in people with Type 2 diabetes, some of which can be used to treat obesity even in people who do not have diabetes

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S8c), except that in our new structure, ECL3 splays out and causes a sharper TM6 kink distinct from the GLP-1-bound active structure as seen from the kink angle (98 and 112 for the ligand-free and GLP-1-bound GLP-1RG s structures, respectively, measured at the C atoms of D344 6.33b P358 6.47b V370 6.59b ) (Fig