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Clinical trials did not test semaglutide at doses higher than 2.4 mg for weight loss, so safety data beyond this level does not exist

Long-term goals Wegovy and Contrave havent been directly compared in a single study, but separate studies suggest Wegovy may lead to more weight loss

Semaglutide activates only the GLP-1 receptor compared to retatrutide triple-agonist approach, producing less weight loss but with a longer safety track record

These could signal dehydration or strain on the organs