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Angelova, P

After crossing the plasma membrane-facilitated by their steroid structure-estrogens bind to cytoplasmic receptors, which translocate to the nucleus and interact with DNA to regulate transcription (Lonard and O'Malley, 2006)

L-carnitine is a key nutrient in cellular metabolism whose main function is to transport fatty acids into mitochondria to be metabolized and used for cell energy production [1]

Specifically, the known surfaces of FBXO22 that interact with BACH1 and BAG3, another known SCF FBXO22 substrate, do not overlap with the region of FBXO22 that contains C326 and engages NSD2 in our structures with either UNC10088 or UNC10415667 13,14,24

Together, we will continue to advance understanding and improve care for people with PWS.