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doi: 10.1007/978-3-030-73234-9_36 4 PykeCHellerRSKirkRKrskovCReedtz-RungeSKaastrupPet al

Content Updated: March 13, 2026 Key takeaways Microdosing with semaglutide involves administering smaller doses than the standard amount

However, the ELIXA (Evaluation of Lixisenatide in Acute Coronary Syndrome) trial found that the once-daily GLP-1 receptor agonist lixisenatide had a neutral effect on cardiovascular outcomes, neither increasing nor decreasing incidence relative to placebo (31)

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