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Dysregulation in iron-sulfur cluster proteins Iron is imported into the mitochondrial matrix by the mitoferrin transporters, mitoferrin 1 (MFRN1) and 2 (MFRN2) (Fig

In summary, AST demonstrates promising therapeutic potential in PD by targeting key pathological mechanisms such as oxidative stress, neuroinflammation, and mitochondrial dysfunction

Combination therapy (ixekizumab + tirzepatide) showed a clear advantage, with nearly one-third of patients achieving the primary endpoint compared to less than 1% with ixekizumab alone