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IL-1, on the other hand, has been shown to interfere with the ion selectivity of tight junctions (Coyne et al., 2002), and, in combination with High Mobility Group Box 1 (HMGB1), induces the downregulation of occludin and claudin-1 and the mislocalization of E-cadherin and -catenin (HUANG et al., 2016)

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Additionally, some metal ions are involved in the regulation of ferroptosis

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T.RhlmannE.WaldeckB.BranscheidD.LutsA.SundlerF.et al (2001)

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Neuromodulators Neuromodulators also known as neurotoxins or toxins or simply Botox work by blocking signals from the nerves to the muscles

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